Understanding how hair cells in the inner ear detect motion and gravity
Diversification of the mechanotransduction complex in vestibular hair cells
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10886798
This study is looking at special hair cells in the inner ear that help us sense gravity and movement, using zebrafish and mice to learn how these cells work differently in various parts of the ear, which could help us understand balance and motion better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10886798 on ClinicalTrials.gov |
What this research studies
This research investigates the specialized hair cells in the vestibular system, which are crucial for sensing gravity and head movements. It focuses on two types of hair cells and how their mechanotransduction machinery varies across different zones within the vestibular organs. By studying the expression of specific proteins in zebrafish and mice, the research aims to uncover the molecular mechanisms that enable these cells to function differently based on their location. This could lead to a better understanding of balance and motion detection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing balance issues or vestibular disorders, particularly those under 21 years old.
Not a fit: Patients with non-vestibular related conditions or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of balance disorders and lead to improved treatments for patients with vestibular dysfunction.
How similar studies have performed: Other research has shown success in understanding mechanotransduction in similar cellular contexts, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NICOLSON, TERESA A — STANFORD UNIVERSITY
- Study coordinator: NICOLSON, TERESA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.