Understanding how Haemophilus ducreyi interacts with the human body.
Determination of the Interactome between Haemophilus ducreyi and the Human Host.
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10757035
This study is looking at how the bacteria that cause chancroid interact with the human body by testing it on adult volunteers, with the goal of finding better ways to treat infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10757035 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular interactions between the bacterium Haemophilus ducreyi, which causes chancroid, and the human host. By using RNA sequencing and metabolomics, the study aims to define the interactome at a transcript level in human volunteers who are experimentally infected. The research involves inoculating the bacteria into the skin of adult participants to observe how the pathogen interacts with the host's immune response and cellular environment. This approach seeks to uncover critical information that could lead to better treatments for infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult volunteers who can participate in experimental infection studies.
Not a fit: Patients who are not adults or those with pre-existing conditions that prevent participation in experimental infection studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for infections caused by Haemophilus ducreyi.
How similar studies have performed: While the approach of studying host-pathogen interactions is established, this specific investigation into Haemophilus ducreyi is novel and has not been extensively tested before.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPINOLA, STANLEY M. — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: SPINOLA, STANLEY M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.