Understanding how H3K27M mutations affect metabolism in childhood brain tumors
Unravelling metabolic dependencies in H3K27M mutant DIPG
This study is looking at how certain changes in brain tumors called DIPGs, which mostly affect kids, impact the way the tumor cells use energy and nutrients, with the hope of finding new ways to treat these tumors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10976915 on NIH RePORTER |
What this research studies
This research investigates the metabolic changes caused by H3K27M mutations in Diffuse Intrinsic Pontine Gliomas (DIPGs), a type of brain tumor that primarily affects children. The study focuses on how these mutations alter cellular metabolism, particularly the production of α-ketoglutarate, which is crucial for maintaining the tumor's epigenetic state. By exploring these metabolic dependencies, the research aims to identify potential therapeutic strategies that could improve treatment outcomes for affected children. The approach includes analyzing tumor samples and utilizing advanced sequencing techniques to understand the underlying mechanisms better.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with H3K27M mutant Diffuse Intrinsic Pontine Gliomas.
Not a fit: Patients without H3K27M mutations or those with other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve survival rates for children with H3K27M mutant DIPGs.
How similar studies have performed: Previous clinical trials have shown promising results with similar approaches, indicating potential for significant advancements in treatment.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Venneti, Sriram — University of Michigan at Ann Arbor
- Study coordinator: Venneti, Sriram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.