Understanding how gut microbes affect immunity in infants exposed to HIV
Identifying inter-kingdom microbial determinants of altered immunity in HIV exposed infants
This study is looking at how the bacteria in the gut of babies born to mothers with HIV might affect their immune system, especially how well they respond to vaccines, to help understand why some of these babies might get sick more easily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11171118 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbes and immune responses in infants born to HIV-infected mothers. It focuses on how specific microbial communities in the gut may influence the development of T cell subsets that are crucial for adaptive immunity. By analyzing the gut microbiota and virome of both HIV-exposed uninfected infants and unexposed infants, the study aims to uncover factors that contribute to reduced vaccine responses and increased disease susceptibility in these vulnerable populations. The research will utilize existing cohort data to explore these interactions over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants born to HIV-infected mothers who are either HIV-exposed uninfected or unexposed.
Not a fit: Patients who are not infants or those who are not born to HIV-infected mothers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and health outcomes for infants exposed to HIV.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Brown, Bryan P — University of California Riverside
- Study coordinator: Brown, Bryan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.