Understanding how gut microbes affect immunity in infants exposed to HIV
Official title: Identifying inter-kingdom microbial determinants of altered immunity in HIV exposed infants
Funded at University of California Riverside · NIH-11171118 · Data updated 2026-11-12
This study is looking at how the bacteria in the gut of babies born to mothers with HIV might affect their immune system, especially how well they respond to vaccines, to help understand why some of these babies might get sick more easily.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | September 12, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HD106861-03 |
| Project ID | NIH-11171118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants born to HIV-infected mothers who are either HIV-exposed uninfected or unexposed.
✕Less likely to help
Patients who are not infants or those who are not born to HIV-infected mothers may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbes and immune responses in infants born to HIV-infected mothers. It focuses on how specific microbial communities in the gut may influence the development of T cell subsets that are crucial for adaptive immunity. By analyzing the gut microbiota and virome of both HIV-exposed uninfected infants and unexposed infants, the study aims to uncover factors that contribute to reduced vaccine responses and increased disease susceptibility in these vulnerable populations. The research will utilize existing cohort data to explore these interactions over time.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and health outcomes for infants exposed to HIV.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Brown, Bryan P — University of California Riverside
- Study coordinator: Brown, Bryan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.