Understanding how gut microbes affect brain communication through a specific enzyme
The role of superoxide dismutase SOD-1 in microbe-gut-brain interaction
['FUNDING_R01'] · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · NIH-10624844
This study is looking at how gut bacteria might help the brain communicate better by focusing on a protein called SOD-1, using tiny worms to see if certain signals from bacteria can affect memory and brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED (nih funded) |
| Locations | 1 site (STRATFORD, UNITED STATES) |
| Trial ID | NIH-10624844 on ClinicalTrials.gov |
What this research studies
This research investigates the role of superoxide dismutase-1 (SOD-1) in how gut microbes influence communication between the gut and the brain. Using the nematode C. elegans, a simple model organism, the research aims to uncover how bacteria activate SOD-1 and whether neuropeptides serve as signaling molecules in this process. By exploring these interactions, the study seeks to enhance our understanding of gut-brain communication and its implications for memory and neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing cognitive decline or neurodegenerative conditions.
Not a fit: Patients who are younger than 21 years old or do not have any cognitive or neurodegenerative issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how gut health impacts brain function and potentially inform treatments for neurodegenerative diseases.
How similar studies have performed: Other research has shown promising results in understanding gut-brain interactions, but the specific role of SOD-1 in this context is relatively novel.
Where this research is happening
STRATFORD, UNITED STATES
- ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED — STRATFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, HOWARD C — ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED
- Study coordinator: CHANG, HOWARD C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.