Understanding how gut immune responses to fungi affect intestinal health.
Regulation and function of mucosal IgA immune responses to mycobiota in the gut.
This study is looking at how a special protein called Immunoglobulin A (IgA) helps keep your gut healthy by working with the fungi that live there, and it’s especially for people with Inflammatory Bowel Disease (IBD) to better understand how to protect their gut from harmful germs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11089591 on NIH RePORTER |
What this research studies
This research investigates the role of Immunoglobulin A (IgA) in the gut and its interaction with the intestinal mycobiota, which includes fungi. It aims to understand how IgA helps maintain gut health by preventing harmful microbes from invading the intestinal lining and how it influences the immune response to these fungi. The study will explore the mechanisms behind antifungal antibody responses and their implications for conditions like Inflammatory Bowel Disease (IBD). By examining genetic factors that affect antifungal immunity, the research seeks to uncover new insights into gut health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Inflammatory Bowel Disease (IBD) or those experiencing gut-related issues linked to fungal infections.
Not a fit: Patients without gastrointestinal conditions or those not affected by fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with gastrointestinal diseases by enhancing our understanding of gut immunity.
How similar studies have performed: While the role of IgA in gut health is established, the specific focus on antifungal responses and mycobiota is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Iliev, Iliyan Dimitrov — Weill Medical Coll of Cornell Univ
- Study coordinator: Iliev, Iliyan Dimitrov
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.