Understanding how gut immune cells respond to different environments in the intestines
Official title: Nuclear Receptor Networks in Mucosal Immune Regulation
Funded at Dartmouth-Hitchcock Clinic · NIH-11078675 · Data updated 2026-11-12
This study is looking at how your gut's immune system works and how it reacts to different substances made by gut bacteria, which could help find better treatments for inflammatory bowel diseases.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $396,660 |
| NIH project number | 5U01AI163063-06 |
| Project ID | NIH-11078675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases, particularly those experiencing symptoms related to the small or large intestine.
✕Less likely to help
Patients without inflammatory bowel diseases or those with other unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates the immune regulation in the gut, focusing on how different types of immune cells in the small and large intestines respond to various metabolites. By examining the role of nuclear receptors in these processes, the study aims to uncover how immune tolerance is shaped by interactions between gut microbes and host cells. The approach includes analyzing the behavior of specific immune cell subsets and their responses to bile acids and other metabolites, which could lead to more targeted treatments for inflammatory bowel diseases.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients with inflammatory bowel diseases like ulcerative colitis and Crohn's disease.
How similar studies have gone: Previous research has shown promising results in understanding immune regulation in the gut, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Dartmouth-Hitchcock Clinic
Lebanon, United States Active
Researchers
- Principal investigator: Sundrud, Mark Scott — Dartmouth-Hitchcock Clinic
- Study coordinator: Sundrud, Mark Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.