Understanding how gut health affects lung immunity
Official title: Epithelial Contributions to Lung Immunity
Funded at University of Colorado Denver · NIH-10995084 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut can affect your lung health and immune system, especially for people dealing with conditions like asthma or pneumonia, to find ways to help your body fight off respiratory infections better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 13, 2024 |
| Project end | September 12, 2025 |
| Funding year | 2024 |
| Award (this year) | $89,488 |
| NIH project number | 1F32HL172725-01A1 |
| Project ID | NIH-10995084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with respiratory conditions such as asthma or those who have experienced recurrent lung infections.
✕Less likely to help
Patients with stable lung conditions and no history of gut-related issues may not receive direct benefits from this research.
What this research studies
This research investigates the role of T-helper (Th)-17 lymphocytes in regulating immune responses in the lungs, particularly how changes in the gut microbiome can influence lung health. It aims to explore the connections between gut health and lung immunity, especially in the context of infections and autoimmune diseases. By examining how factors like diet and antibiotic use affect the gut microbiome, the study seeks to uncover mechanisms that could improve host defense against respiratory infections. Patients may benefit from insights that could lead to better management of conditions like asthma and pneumonia.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory infections and autoimmune diseases by enhancing our understanding of gut-lung interactions.
How similar studies have gone: Previous research has shown promising results in understanding the gut-lung axis, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Orlov, Marika — University of Colorado Denver
- Study coordinator: Orlov, Marika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.