Understanding how gut fungi affect immune responses and inflammation.
Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity.
This study is looking at how certain fungi in the gut might affect inflammation and immune responses in people with ulcerative colitis, and it hopes to find new ways to help manage this condition by understanding how these fungi interact with the immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10840824 on NIH RePORTER |
What this research studies
This research investigates the role of intestinal fungi in regulating immune responses and inflammation, particularly in conditions like ulcerative colitis. It explores how specific genetic variations in the anti-fungal receptor Dectin-1 may influence the severity of inflammatory diseases. By studying the interactions between gut fungi and immune cells, the research aims to uncover mechanisms that could lead to new therapeutic strategies for managing inflammatory conditions. Patients may benefit from insights into how their gut microbiota affects their health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ulcerative colitis or other inflammatory bowel diseases.
Not a fit: Patients without gastrointestinal conditions or those not affected by fungal infections may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for inflammatory diseases like ulcerative colitis by targeting gut fungi and enhancing immune responses.
How similar studies have performed: Other research has shown promising results in understanding the role of microbiota in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Iliev, Iliyan Dimitrov — Weill Medical Coll of Cornell Univ
- Study coordinator: Iliev, Iliyan Dimitrov
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.