Understanding how gut cells respond to bacteria
Epigenetic regulation of intestinal tuft cells
This study is looking at how special cells in your gut, called tuft cells, work with bacteria to keep your immune system balanced and your gut healthy, and it hopes to find new ways to help people with intestinal diseases like Crohn's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10994224 on NIH RePORTER |
What this research studies
This research investigates how specialized cells in the intestine, known as tuft cells, interact with bacteria to regulate immune responses and maintain gut health. The study focuses on the role of epigenetics, which involves changes in gene expression without altering the DNA sequence, in controlling tuft cell development and function. By examining how different bacteria and their metabolites influence these cells, the research aims to uncover mechanisms that could lead to better treatments for intestinal diseases like Crohn's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from Crohn's disease or other intestinal disorders who may benefit from improved understanding and treatment options.
Not a fit: Patients with non-intestinal related conditions or those not affected by Crohn's disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve gut health and manage conditions like Crohn's disease more effectively.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota in intestinal health, suggesting that this approach could yield significant insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Alenghat, Theresa — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Alenghat, Theresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.