Understanding how gut cells interact with gut bacteria using a simple worm model.
Caenorhabditis Elegans: a Model for Genetic Interaction between the Gut Microbiota and Intestinal Epithelial Cells
This study looks at how tiny worms help us understand how our gut cells tell the difference between good and bad bacteria, which is important for keeping our digestive system healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-10896475 on NIH RePORTER |
What this research studies
This research investigates the interactions between intestinal epithelial cells and gut microbiota using the model organism Caenorhabditis elegans. By studying these interactions, the research aims to uncover how intestinal cells differentiate between beneficial and harmful bacteria, which is crucial for maintaining gut health. The approach involves observing the responses of these cells to various gut bacteria, providing insights into the mechanisms that govern gut microbial communities. This could lead to a better understanding of how dysbiosis contributes to diseases and how to promote healthy gut flora.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gut health or dysbiosis, particularly those under 21 years old.
Not a fit: Patients with no gastrointestinal issues or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating diseases linked to gut microbiota imbalances.
How similar studies have performed: Previous research has shown promising results in understanding gut microbiota interactions using model organisms, indicating potential for success in this approach.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Hill, Jessica L — Colorado State University
- Study coordinator: Hill, Jessica L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.