Understanding how gut cells interact to heal injured intestines in newborns
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
This study looks at how certain cells in the intestines of newborn pigs work together to help heal injuries, like those caused by necrotizing enterocolitis, with the hope of finding new ways to support recovery in babies with similar intestinal issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10655459 on NIH RePORTER |
What this research studies
This research investigates the interactions between enteric glial cells and epithelial cells in the intestines of newborns, particularly focusing on how these interactions can aid in the repair of intestinal injuries caused by conditions like necrotizing enterocolitis. The study uses juvenile pigs to explore the mechanisms of intestinal repair and the role of specific cell populations in promoting healing. By examining how these cells communicate and stimulate cell migration, the research aims to uncover potential therapeutic targets for improving recovery in neonates with intestinal injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are neonates or infants who have experienced intestinal injuries or are at risk for conditions like necrotizing enterocolitis.
Not a fit: Patients who are older children or adults with gastrointestinal issues may not benefit from this research focused on neonatal intestinal repair.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance intestinal healing in newborns, potentially reducing mortality rates associated with intestinal injuries.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding cell interactions in tissue repair, indicating potential for meaningful advancements.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Blikslager, Anthony — North Carolina State University Raleigh
- Study coordinator: Blikslager, Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.