Understanding How Gut Cells Change Their Energy Use
Mechanisms Driving Metabolic Shifts in the Intestinal Epithelium
This research explores how cells in your gut change their energy use, aiming to find new ways to help with intestinal diseases and colon cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-11098459 on NIH RePORTER |
What this research studies
Our gut cells constantly change how they use energy, which is important for keeping the intestine healthy and also plays a role in conditions like colon cancer. We are looking closely at how a specific protein, called YY1, helps control these energy changes in different types of gut cells. By understanding these detailed processes, we hope to uncover new targets for future treatments. This work uses advanced lab techniques and special mouse models to reveal these hidden mechanisms.
Who could benefit from this research
Good fit: Patients with intestinal diseases or colon cancer could potentially benefit from future therapies developed from this foundational understanding.
Not a fit: Patients without intestinal conditions or those not seeking new therapeutic approaches for metabolic regulation may not directly benefit.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for various intestinal diseases and colon cancer by targeting how gut cells manage their energy.
How similar studies have performed: This research builds upon existing knowledge of cellular metabolism but explores novel regulatory mechanisms in the intestine using new mouse models.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Verzi, Michael P. — Rutgers, the State Univ of N.j.
- Study coordinator: Verzi, Michael P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.