Understanding how gut cells affect gastrointestinal complications after stem cell transplants
Intestinal tissue intrinsic mechanisms in regulation of GI GVHD
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11090483
This study is looking at how certain cells in the gut can affect the severity of gastrointestinal graft-versus-host disease (GI GVHD) after a stem cell transplant, and it aims to find new ways to help prevent and treat this condition without using strong medications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11090483 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which intestinal epithelial cells (IECs) influence the severity of gastrointestinal graft-versus-host disease (GI GVHD) following allogeneic hematopoietic cell transplantation. The team aims to identify metabolic changes in these gut cells that contribute to the condition, focusing on a specific mitochondrial component called succinate dehydrogenase A (SDHA). By exploring how these metabolic pathways affect intestinal stem cells, the research seeks to develop non-immunosuppressive strategies to prevent and treat GI GVHD, potentially improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone allogeneic hematopoietic cell transplantation and are at risk for gastrointestinal GVHD.
Not a fit: Patients who have not undergone stem cell transplantation or those without gastrointestinal complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of gastrointestinal complications in patients undergoing stem cell transplants.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways in similar contexts, suggesting potential for success in this novel approach.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REDDY, PAVAN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: REDDY, PAVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases, blood disorder