Understanding how gut barrier issues contribute to food allergies
The role of epithelial barrier dysfunction in food anaphylaxis
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10861868
This study is looking at how problems with the skin barrier might be linked to food allergies in kids, and it hopes to find out if certain genes play a role in these allergies, so we can better understand why some children have severe reactions to foods.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10861868 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between epithelial barrier dysfunction and food anaphylaxis, particularly in children. It aims to identify genetic factors that may influence the development of food allergies and assess how skin barrier measurements can predict reactions to food challenges. By utilizing a biorepository of samples from children with food allergies, the study will provide insights into the mechanisms behind these allergic reactions. The research is conducted at the University of Michigan, where a team of experienced mentors will guide the project.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with food allergies, particularly those with severe reactions.
Not a fit: Patients who do not have food allergies or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for children suffering from food allergies.
How similar studies have performed: Previous research has shown promising results in understanding the role of epithelial barriers in allergies, suggesting that this approach may yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHULER, CHARLES F — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: SCHULER, CHARLES F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.