Understanding how gut bacteria secrete proteins and affect metabolism
Mechanistic investigation of bacterial type 9 secretion system machinery and its involvement in gut metabolism and immunomodulation
This study is looking at how certain gut bacteria help break down fiber from our food and produce helpful substances for our health, which could lead to new ways to improve gut health and prevent diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10893016 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which gut bacteria, specifically the Bacteroides genus, secrete proteins that play a crucial role in breaking down dietary fibers and producing beneficial metabolites. By developing a genetically modified strain of Bacteroides intestinalis, the research aims to explore how these bacteria utilize host substrates to generate short-chain fatty acids (SCFAs), which are vital for metabolic health. The study will also examine the secretome, a collection of proteins secreted by these bacteria, to understand its impact on gut health and metabolism. This research could lead to new insights into how gut microbiota contribute to overall health and disease prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or those interested in gut health and microbiota.
Not a fit: Patients with conditions unrelated to gut health or metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gut health and lead to new strategies for preventing metabolic disorders.
How similar studies have performed: While the specific approach of studying the Type 9 secretion system in gut bacteria is relatively novel, similar research has shown promising results in understanding gut microbiota's role in health.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Shrivastava, Abhishek — Arizona State University-Tempe Campus
- Study coordinator: Shrivastava, Abhishek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.