Understanding how gut bacteria modify bile acids and their effects on health and disease
Activity-based profiling of bile salt hydrolases in the gut microbiome in health and disease
This study is looking at how the bacteria in your gut change bile acids, which are important for digestion, to better understand how these changes might affect your health and immune system, so that we can learn more about how gut bacteria can help with different health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10662294 on NIH RePORTER |
What this research studies
This research investigates the role of gut bacteria in modifying bile acids, which are important for digestion and overall health. By developing specialized chemical probes, the study aims to identify and analyze the activity of specific enzymes produced by these bacteria, known as bile salt hydrolases. This approach will help researchers understand how these enzymes contribute to the production of metabolites that can influence immunity and disease processes. Patients may benefit from insights gained about the gut microbiome's role in various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in the impact of gut health on overall well-being.
Not a fit: Patients with no gastrointestinal issues or those not interested in the role of gut microbiota may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving gut health and managing diseases linked to gut microbiota.
How similar studies have performed: Previous research has shown promising results in understanding the gut microbiome's role in health, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Chang, Pamela Vivian — Cornell University
- Study coordinator: Chang, Pamela Vivian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.