Understanding how gut bacteria metabolites affect immune cells in bowel inflammation
Official title: Role of SLCO3A1 in macrophage metabolite sensing and IBD
Funded at Mayo Clinic Rochester · NIH-11001222 · Data updated 2026-11-12
This study is looking at how certain immune cells in your gut help control inflammation, especially for people with inflammatory bowel disease (IBD), by understanding how they react to substances made by gut bacteria, which could lead to better ways to support gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 6, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $349,800 |
| NIH project number | 5R01DK130854-03 |
| Project ID | NIH-11001222 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease or those experiencing chronic gut inflammation.
✕Less likely to help
Patients without gastrointestinal issues or those not suffering from inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of macrophages, a type of immune cell, in managing inflammation in the gut, particularly in conditions like inflammatory bowel disease (IBD). It focuses on how these cells sense and respond to metabolites produced by gut bacteria, such as short-chain fatty acids and bile acids, which can influence their inflammatory responses. By exploring the transport proteins that help these metabolites enter macrophages, the research aims to uncover new ways to enhance the immune response and restore balance in gut health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve immune function and reduce inflammation in patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in immune regulation, suggesting that this approach could yield significant insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Ip, W. K. Eddie — Mayo Clinic Rochester
- Study coordinator: Ip, W. K. Eddie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.