Understanding how gut bacteria may influence the onset of type 1 diabetes in young children
Official title: Investigate the Role of Gut Microbiota in the Development of Type 1 Diabetes Using TEDDY Study
Funded at New York University School of Medicine · NIH-11045682 · Data updated 2026-11-12
This study is looking at how the bacteria in the gut might affect the chances of infants and young children developing type 1 diabetes, and it’s for families with kids who are at risk for this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $169,500 |
| NIH project number | 5R03DK138490-02 |
| Project ID | NIH-11045682 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and young children who are at high risk for developing type 1 diabetes, particularly those with a family history of the disease.
✕Less likely to help
Patients who are older than 4 years or those who do not have a family history of type 1 diabetes may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiota and the development of type 1 diabetes (T1D) in infants and young children. By analyzing data from the TEDDY study, which follows children at risk for T1D, the researchers aim to identify specific microbial factors that may contribute to the disease. The study will utilize advanced modeling techniques to examine how changes in gut bacteria over time correlate with the onset of islet autoimmunity and T1D. This approach seeks to provide insights into the role of gut health in diabetes development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of type 1 diabetes in at-risk children.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Hu, Jiyuan — New York University School of Medicine
- Study coordinator: Hu, Jiyuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.