Understanding how gut bacteria interact with Yersinia enterocolitica
Official title: Mechanisms of Yersinia Enterocolitica Interaction with the Gut Microbiota
Funded at University of California at Davis · NIH-11038915 · Data updated 2026-11-12
This study is looking at how the good bacteria in our gut can help keep us safe from infections caused by a harmful germ that can come from food, and it focuses on special substances made by these bacteria that might stop the germ from growing.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | November 8, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $195,213 |
| NIH project number | 1R21AI188307-01 |
| Project ID | NIH-11038915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal issues or those at risk of foodborne illnesses.
✕Less likely to help
Patients with non-gastrointestinal conditions or those not affected by enteric pathogens may not benefit from this research.
What this research studies
This research investigates how the gut microbiota helps protect against infections caused by the bacteria Yersinia enterocolitica, which is known to cause foodborne illnesses. The study focuses on short chain fatty acids, which are produced by gut bacteria and play a crucial role in this protective mechanism. Researchers will explore the conditions under which these fatty acids can inhibit the growth of pathogens and will use laboratory and mouse models to test their hypotheses. By understanding these interactions, the research aims to uncover new insights into gut health and infection resistance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by harmful gut bacteria.
How similar studies have gone: Previous research has shown that understanding gut microbiota interactions can lead to significant advancements in infection prevention, indicating potential success for this approach.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Winter, Sebastian E — University of California at Davis
- Study coordinator: Winter, Sebastian E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.