Understanding how gut bacteria influence liver glucose production
Leveraging the Gut Microbiome to Regulate Hepatic Gluconeogenesis
This study is looking at how the bacteria in our gut might help control sugar production in the liver, which could lead to new treatments for people with non-alcoholic fatty liver disease (NAFLD).
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10982497 on NIH RePORTER |
What this research studies
This research investigates the role of gut microbes in regulating glucose production in the liver, particularly in the context of non-alcoholic fatty liver disease (NAFLD). By studying how specific microbial metabolites affect liver function, the research aims to uncover mechanisms that could lead to new treatments for this prevalent chronic condition. The approach involves using animal models to identify which gut bacteria and their metabolites are involved in this regulation, potentially leading to insights that could benefit patients with liver disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease or those at risk for liver-related complications.
Not a fit: Patients with liver diseases unrelated to metabolic processes or those who do not have a significant gut microbiome component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing non-alcoholic fatty liver disease and improving liver health.
How similar studies have performed: Previous research has shown promising results in understanding the gut-liver axis, suggesting that this approach could yield significant insights and potential breakthroughs.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Krisko, Tibor — Weill Medical Coll of Cornell Univ
- Study coordinator: Krisko, Tibor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.