Understanding how gut bacteria influence immune responses after a stroke
Official title: The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
Funded at Weill Medical Coll of Cornell Univ · NIH-11035216 · Data updated 2026-11-12
This study is looking at how certain immune cells and gut bacteria work together after a stroke to affect healing and inflammation, with the hope of finding new ways to help stroke patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $409,628 |
| NIH project number | 5R01NS132493-03 |
| Project ID | NIH-11035216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are interested in potential new treatment options.
✕Less likely to help
Patients who have not had a stroke or those with chronic neurological conditions unrelated to ischemic stroke may not benefit from this research.
What this research studies
This research investigates the role of dendritic cells and gut microbiota in regulating immune responses following ischemic stroke. By examining how these factors contribute to inflammation and tissue injury, the study aims to uncover new therapeutic strategies for stroke patients. The approach includes analyzing the interactions between gut bacteria and immune cells to better understand their impact on recovery after a stroke. Patients may benefit from insights that could lead to innovative treatments targeting immune modulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery and outcomes for stroke patients by targeting immune responses.
How similar studies have gone: Previous research has shown promising results in understanding the gut-brain axis and its influence on immune responses, suggesting potential for success in this novel approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Anrather, Josef — Weill Medical Coll of Cornell Univ
- Study coordinator: Anrather, Josef
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
-
Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.