Understanding how gut bacteria influence immune cells in the brain
Investigating the mechanism and role of the steady-state CXCR3-CXCL10 gut-microbiota-brain T cell axis
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-11044978
This study is looking at how the bacteria in our gut can change the way certain immune cells in the brain work, which could help us understand more about brain health and conditions that affect it.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11044978 on ClinicalTrials.gov |
What this research studies
This research investigates the unique immune response of the brain compared to the rest of the body, focusing on how gut bacteria affect T cells in the brain. It examines the role of specific immune cells, particularly CD4 T cells, and how their presence and function can be altered by changes in gut microbiota. By using mouse models, the study aims to uncover the mechanisms behind T cell trafficking to the brain and how these processes might influence neurological health.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with conditions that may be influenced by gut-brain interactions, particularly those with neurological disorders.
Not a fit: Patients with purely peripheral immune disorders unrelated to brain function or gut health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how gut health impacts brain function and immune responses, potentially informing treatments for neurological diseases.
How similar studies have performed: Previous research has shown promising results in understanding the gut-brain axis, but this specific investigation into steady-state conditions is relatively novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YOSHIDA, TOMOMI MARIE — YALE UNIVERSITY
- Study coordinator: YOSHIDA, TOMOMI MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.