Understanding how gut bacteria influence gut health and inflammation
Official title: Elucidating the role of the microbiome in inducing gut permeability and inflammation
Funded at University of Wisconsin-Madison · NIH-10993154 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut produce substances that can impact gut health and inflammation, which are important for people with metabolic syndrome, and it aims to find out if changing these bacteria can help improve conditions like Non-Alcoholic Steatohepatitis (NASH).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $242,477 |
| NIH project number | 5R00DK128503-04 |
| Project ID | NIH-10993154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from inflammatory diseases or metabolic syndrome, particularly those with conditions like Non-Alcoholic Steatohepatitis.
✕Less likely to help
Patients without any gastrointestinal issues or metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of gut bacteria in producing metabolites that affect gut permeability and inflammation, which are key factors in metabolic syndrome. By analyzing samples from both human patients and rodent models, the study aims to identify specific bile acids and folate metabolites that differ in individuals with inflammatory diseases compared to healthy individuals. The research will explore how these metabolites influence gut health and whether targeting bacterial processes can improve conditions like Non-Alcoholic Steatohepatitis (NASH).
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve gut health and reduce inflammation in patients with metabolic disorders.
How similar studies have gone: Previous research has shown promising results in understanding the microbiome's role in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Chaudhari, Snehal N. — University of Wisconsin-Madison
- Study coordinator: Chaudhari, Snehal N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.