Understanding how gut bacteria influence colorectal cancer development
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
This study is looking at how changes in the bacteria in your gut might be linked to the development of colon issues like polyps and cancer, and it involves patients sharing samples to help us understand this connection better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11042859 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiome disturbances and the development of colorectal neoplasia, including adenomas and colorectal cancer. By analyzing multi-omics data, the study aims to uncover how specific gut microbes, such as Bacteroides fragilis, affect DNA methylation and gene expression in colon tissues. The research utilizes data from large population-based studies to establish a causal link between the microbiome and colorectal cancer. Patients may be involved in providing samples or data to help elucidate these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of colorectal adenomas or those at high risk for colorectal cancer.
Not a fit: Patients without any history of colorectal neoplasia or those with unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies or treatments for colorectal cancer by targeting gut microbiome factors.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Yang, Yaohua — University of Virginia
- Study coordinator: Yang, Yaohua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.