Understanding how gut bacteria influence blood sugar and amino acids
Official title: Molecular mechanisms behind microbiota regulation of host amino acid and glucose homeostasis
Funded at Weill Medical Coll of Cornell Univ · NIH-11083753 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut might help manage type 2 diabetes by affecting how our bodies process certain nutrients, and it's hoping to find ways to use these bacteria to improve diabetes care for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $491,469 |
| NIH project number | 5R01DK135816-03 |
| Project ID | NIH-11083753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with type 2 diabetes, particularly older adults.
✕Less likely to help
Patients who do not have type 2 diabetes or are not at risk for developing it may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiota and type 2 diabetes (T2D), particularly how gut bacteria affect amino acid metabolism and glucose regulation. By using advanced techniques in bioinformatics and metabolomics, the study aims to identify specific microbes that influence these metabolic pathways in mouse models of T2D. The ultimate goal is to develop engineered gut microbial communities that could help prevent or treat T2D in humans. This research could provide insights into the causal links between gut health and diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating type 2 diabetes through targeted manipulation of gut microbiota.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in metabolic diseases, suggesting that this approach could yield significant insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Guo, Chun-Jun — Weill Medical Coll of Cornell Univ
- Study coordinator: Guo, Chun-Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.