Understanding how gut bacteria compete with Salmonella infections
Official title: Metatranslatomics enables functional profiling of microbial competition in the Salmonella-perturbed gut
Funded at University of California, San Diego · NIH-10996025 · Data updated 2026-11-12
This study is looking at how Salmonella bacteria interact with the good bacteria in our gut during an infection, to find out how Salmonella manages to survive and thrive, which could help develop better treatments for Salmonella infections and improve gut health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 17, 2024 |
| Project end | July 16, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,032 |
| NIH project number | 1F31AI186410-01 |
| Project ID | NIH-10996025 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced Salmonella infections or are at risk of such infections due to compromised gut health.
✕Less likely to help
Patients who do not have a history of Salmonella infections or related gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the interactions between Salmonella Typhimurium and the gut microbiota, focusing on how these bacteria compete for resources during infection. By using advanced techniques like metagenomics and metatranslatomics, the study aims to uncover the mechanisms that allow Salmonella to thrive in the gut despite the presence of beneficial bacteria. Patients may benefit from insights that could lead to new, targeted therapies for Salmonella infections, reducing reliance on broad-spectrum antibiotics that can worsen inflammation. The research seeks to enhance our understanding of gut health and its role in preventing infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target Salmonella infections without harming beneficial gut bacteria.
How similar studies have gone: Other research has shown promise in understanding microbial interactions in the gut, suggesting that targeted approaches could be effective in managing infections.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Norton, Grant J — University of California, San Diego
- Study coordinator: Norton, Grant J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.