Understanding how gut bacteria communicate with the body
Microbial Chemical Sensing and Host Responses
This study is looking at how the tiny organisms in our gut produce substances that can affect our health, and it's for anyone interested in understanding how these substances might influence our body's functions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11049199 on NIH RePORTER |
What this research studies
This research investigates the vast array of microbial metabolites produced by gut bacteria and their effects on human health. It aims to uncover how these metabolites interact with the body's signaling systems, particularly through G protein-coupled receptors (GPCRs). By analyzing various gut bacteria and their secretions, the study seeks to identify novel small molecules that could influence physiological processes. The research employs high-throughput screening methods to explore the complex interactions between gut bacteria and host metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with gastrointestinal disorders or those interested in understanding the role of gut bacteria in health and disease.
Not a fit: Patients who do not have any gastrointestinal issues or are not interested in the microbiome's impact on health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gut health and the development of targeted therapies for various diseases.
How similar studies have performed: Other research has shown promising results in understanding the microbiome's role in health, indicating that this approach has potential for significant discoveries.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Crawford, Jason Michael — Yale University
- Study coordinator: Crawford, Jason Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.