Understanding how gut bacteria changes after weight loss surgery can improve heart function.
Official title: Identifying Gut Microbiome Mediated Mechanisms for Diastolic Dysfunction Improvement After Bariatric Surgery
Funded at Medical College of Wisconsin · NIH-11103193 · Data updated 2026-11-12
This study is looking at how sleeve gastrectomy, a type of weight-loss surgery, can help improve heart function in people with obesity-related heart issues by examining changes in gut bacteria and bile acids after the surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $396,578 |
| NIH project number | 5R01HL158900-04 |
| Project ID | NIH-11103193 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are undergoing or have undergone sleeve gastrectomy and have obesity-related diastolic dysfunction.
✕Less likely to help
Patients who do not have obesity-related heart issues or have not undergone bariatric surgery may not benefit from this research.
What this research studies
This research investigates how bariatric surgery, specifically sleeve gastrectomy, can improve heart function in patients with obesity-related diastolic dysfunction. It focuses on the changes in gut microbiome after surgery and how these changes may lead to the production of specific bile acids that positively affect heart health. The study will involve analyzing stool samples from both humans and animal models to understand the relationship between gut bacteria and heart function. Additionally, it will explore how these bile acids can reduce stress on heart cells, potentially leading to better cardiac outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for improving heart function in patients with obesity-related heart issues.
How similar studies have gone: Previous research has shown promising results in understanding the gut-heart connection, making this approach both relevant and potentially impactful.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Kindel, Tammy Lyn — Medical College of Wisconsin
- Study coordinator: Kindel, Tammy Lyn
Related research
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This study looks at how gut microbes and bile acids after sleeve gastrectomy might improve heart function in people with obesity-related diastolic problems.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.