Understanding how gut bacteria cause abdominal pain
Official title: MECHANISMS OF VISCERAL PAIN DRIVEN BY SMALL INTESTINAL MICROBIOTA
Funded at Mayo Clinic Rochester · NIH-10931675 · Data updated 2026-11-12
This study is looking at how the tiny bacteria in your gut might be causing abdominal pain if you have irritable bowel syndrome (IBS), and it hopes to find new ways to help you feel better by understanding how these bacteria communicate with your nervous system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 19, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $767,885 |
| NIH project number | 5R01DK138818-02 |
| Project ID | NIH-10931675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with irritable bowel syndrome who experience frequent abdominal pain.
✕Less likely to help
Patients with abdominal pain not related to gut microbiota or those with other gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the role of small intestinal microbiota in causing abdominal pain, particularly in patients with irritable bowel syndrome (IBS). By examining how gut bacteria and their products signal to the nervous system, the study aims to uncover the mechanisms behind visceral pain. The approach includes using advanced techniques like gene sequencing and animal models to explore the interactions between gut microbes and sensory pathways. Patients may gain insights into the biological factors contributing to their symptoms and potential new treatment avenues.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for managing abdominal pain in IBS patients.
How similar studies have gone: Previous research has shown promising results in understanding gut microbiota's role in gastrointestinal symptoms, suggesting potential for success in this novel approach.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kashyap, Purna C — Mayo Clinic Rochester
- Study coordinator: Kashyap, Purna C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.