Understanding how gut bacteria and immune responses affect cancer spread
Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis
This study is looking at how certain gut bacteria and immune system antibodies might affect cancer spread in older adults, and it hopes to find ways to improve cancer treatment by understanding these connections better, so patients may be asked to share samples or information to help with the research.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10758543 on NIH RePORTER |
What this research studies
This research investigates the relationship between immunoglobulin G (IgG) antibodies and the gut microbiome in the context of cancer progression and metastasis. It aims to uncover how interactions between gut bacteria and the immune system can influence the spread of cancer, particularly in older adults. By identifying specific gut microbes linked to metastatic risk and exploring how these interactions can be leveraged to improve immunotherapy outcomes, the study seeks to enhance our understanding of cancer biology. Patients may be involved in providing samples or data to help elucidate these complex relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults diagnosed with cancer who are undergoing or considering immunotherapy.
Not a fit: Patients with non-cancerous conditions or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancer metastasis by targeting gut microbiome interactions.
How similar studies have performed: Previous research has shown promising results in understanding the role of the gut microbiome in cancer treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Zeng, Melody Y — Weill Medical Coll of Cornell Univ
- Study coordinator: Zeng, Melody Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.