Understanding how gut bacteria and immune responses affect ALS progression
RFA-TS-22-001: Interactions between the microbiome, metabolome, and immune system as underlying mechanisms of ALS pathogenesis
This study is looking at how the bacteria in your gut, the substances your body makes, and your immune system work together in people with ALS, hoping to find new insights that could lead to better treatments and understanding of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10873658 on NIH RePORTER |
What this research studies
This research investigates the connections between the gut microbiome, metabolites, and the immune system in patients with amyotrophic lateral sclerosis (ALS). By analyzing how these biological systems interact, the study aims to uncover mechanisms that contribute to the progression of ALS. Researchers will utilize existing data from ongoing ALS studies to identify patterns and associations that may inform future therapies. The goal is to enhance our understanding of ALS and potentially identify new biomarkers for the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis (ALS).
Not a fit: Patients with other neurodegenerative diseases or those without a diagnosis of ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and improved treatment options for ALS patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome in various diseases, suggesting potential for success in this novel approach to ALS.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Murdock, Benjamin Joseph — University of Michigan at Ann Arbor
- Study coordinator: Murdock, Benjamin Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.