Understanding how gut bacteria and diet affect body weight
Official title: Defining the Quantitative Functional Mechanisms that Underly Gut Microbiome-Diet Interactions Contributing to Human Energy Balance
Funded at Adventhealth Orlando · NIH-11136388 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut and what we eat can affect our weight, and it’s for anyone interested in understanding how different diets might help with managing obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | July 15, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $568,099 |
| NIH project number | 5R01DK140328-02 |
| Project ID | NIH-11136388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or those interested in understanding how diet affects their weight.
✕Less likely to help
Patients who are not overweight or do not have concerns related to body weight may not benefit from this research.
What this research studies
This research investigates the relationship between the gut microbiome and energy balance in humans, particularly how different diets influence body weight. By conducting a controlled feeding study, researchers will analyze how specific dietary components affect energy intake, expenditure, and fecal energy loss. The study aims to uncover the mechanisms through which gut bacteria interact with diet to impact weight management, potentially leading to new therapeutic approaches for obesity.
Why it matters
Potential benefit: If successful, this research could lead to innovative dietary strategies or microbiome-targeted therapies for effective weight management.
How similar studies have gone: Previous research has shown promising results in understanding the role of the gut microbiome in weight regulation, but this study aims to provide deeper insights into the specific mechanisms involved.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Corbin, Karen Davidowitz — Adventhealth Orlando
- Study coordinator: Corbin, Karen Davidowitz
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.