Understanding how gut bacteria affect urine oxalate levels
Official title: The role of the microbiome and other host related factors in determining urine oxalate levels
Funded at New York University School of Medicine · NIH-10900154 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect the levels of oxalate in your urine, which is important for people dealing with kidney stones and chronic kidney disease, to find out if certain good bacteria can help lower those oxalate levels and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 16, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $771,555 |
| NIH project number | 1R01DK137473-01A1 |
| Project ID | NIH-10900154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of kidney stones or chronic kidney disease, particularly those who are classified as stone formers.
✕Less likely to help
Patients who do not have kidney stones or chronic kidney disease may not benefit from this research.
What this research studies
This research investigates the relationship between the gut microbiome and urine oxalate levels, which are important for understanding kidney stones and chronic kidney disease. It focuses on how different bacteria in the gut can influence the absorption and synthesis of oxalate in the body. By studying participants from the Nurses' Health Study II, the research aims to identify specific bacterial species that may help lower urine oxalate levels, potentially leading to new treatment options for those affected by kidney stones and chronic kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help reduce urine oxalate levels, potentially preventing kidney stones and slowing the progression of chronic kidney disease.
How similar studies have gone: Previous research has shown that manipulating gut bacteria can influence oxalate metabolism, suggesting that this approach may be promising.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Nazzal, Lama — New York University School of Medicine
- Study coordinator: Nazzal, Lama
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.