Understanding how gut bacteria affect urine oxalate levels
The role of the microbiome and other host related factors in determining urine oxalate levels
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10900154
This study is looking at how the bacteria in your gut might affect the levels of oxalate in your urine, which is important for people dealing with kidney stones and chronic kidney disease, to find out if certain good bacteria can help lower those oxalate levels and improve treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10900154 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the gut microbiome and urine oxalate levels, which are important for understanding kidney stones and chronic kidney disease. It focuses on how different bacteria in the gut can influence the absorption and synthesis of oxalate in the body. By studying participants from the Nurses' Health Study II, the research aims to identify specific bacterial species that may help lower urine oxalate levels, potentially leading to new treatment options for those affected by kidney stones and chronic kidney disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of kidney stones or chronic kidney disease, particularly those who are classified as stone formers.
Not a fit: Patients who do not have kidney stones or chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help reduce urine oxalate levels, potentially preventing kidney stones and slowing the progression of chronic kidney disease.
How similar studies have performed: Previous research has shown that manipulating gut bacteria can influence oxalate metabolism, suggesting that this approach may be promising.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAZZAL, LAMA — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: NAZZAL, LAMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.