Understanding how gut bacteria affect responses to cholera vaccines
Official title: Defining the impact of interpersonal gut microbiota variation on oral cholera vaccine responsiveness
Funded at University of California Riverside · NIH-10999443 · Data updated 2026-11-12
This study is looking at how the different types of bacteria in our guts can affect how well oral cholera vaccines work for children living in areas where cholera is common, with the hope of finding ways to make the vaccines more effective for those who need them most.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | December 11, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $756,395 |
| NIH project number | 5R01AI181382-02 |
| Project ID | NIH-10999443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children aged 0-11 years living in cholera-endemic areas.
✕Less likely to help
Patients who are not children or those living outside cholera-endemic regions may not benefit from this research.
What this research studies
This research investigates how variations in gut microbiota among individuals influence the effectiveness of oral cholera vaccines (OCVs). By analyzing the gut bacteria of children in cholera-endemic areas, the study aims to identify specific microbial populations that correlate with better or worse vaccine responses. The researchers will use advanced techniques to assess immune responses and the role of gut bacteria in shaping these responses. This could lead to strategies that enhance vaccine efficacy in vulnerable populations.
Why it matters
Potential benefit: If successful, this research could lead to improved cholera vaccine effectiveness, particularly in children living in endemic regions.
How similar studies have gone: Previous research has shown that gut microbiota can influence vaccine responses, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Hsiao, Ansel — University of California Riverside
- Study coordinator: Hsiao, Ansel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.