Understanding how gut bacteria affect oxalate metabolism and kidney stone formation
The role of acetogenic, methanogenic, and sulfate-reducing bacteria in oxalate metabolism and hyperoxaluria
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10794275
This study is looking at how different types of gut bacteria work together to break down oxalate, a substance that can lead to kidney stones, to help people understand how their gut health might affect their risk of developing these stones.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10794275 on ClinicalTrials.gov |
What this research studies
This research investigates the role of various gut bacteria in the metabolism of oxalate, a compound linked to the formation of kidney stones. It challenges the traditional view that a single type of bacteria is responsible for breaking down oxalate and instead proposes that a diverse community of bacteria works together to manage oxalate levels in the body. By studying these bacteria and their interactions, the research aims to uncover new insights into how they can help prevent urinary stone disease, which affects a significant portion of the population. Patients may benefit from a better understanding of how their gut microbiome influences their risk of developing kidney stones.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of urinary stone disease or those at risk of developing kidney stones.
Not a fit: Patients who do not have urinary stone disease or related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing kidney stones by targeting gut bacteria.
How similar studies have performed: Previous research has shown that gut bacteria play a significant role in various metabolic processes, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, AARON W — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: MILLER, AARON W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.