Understanding how gut bacteria affect inflammatory bowel disease using a special model.
Deciphering the Role of Gut Microbiome in Inflammatory Bowel Disease Using a Canine Patient-Specific Gut-on-a-Chip
This study is exploring how the bacteria in the gut affect inflammatory bowel disease (IBD) by using dogs to create a model that helps us understand the disease better, so we can find new ways to help people with IBD.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-11001438 on NIH RePORTER |
What this research studies
This research investigates the role of gut microbiome in inflammatory bowel disease (IBD) by creating a patient-specific model using canine subjects. The approach involves advanced techniques like 16S gene sequencing to analyze the microbial communities in the gut and their interactions with host cells. By employing microfluidic organ-on-a-chip technology, the study aims to replicate the gut environment and assess how changes in the microbiome influence IBD. This innovative methodology allows for a detailed understanding of the cellular and molecular mechanisms involved in the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those who may benefit from insights into the role of gut microbiome.
Not a fit: Patients without inflammatory bowel disease or those who do not have a canine model for study may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for inflammatory bowel disease, potentially improving the quality of life for patients.
How similar studies have performed: Other research has shown promise in understanding gut microbiome interactions in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Ambrosini, Yoko Miyamoto — Washington State University
- Study coordinator: Ambrosini, Yoko Miyamoto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.