Understanding how gut bacteria affect inflammation and diabetes
Official title: Genetic determinants of Bacteroides vulgatus colonization fitness and host inflammatory responses
Funded at Duke University · NIH-11083754 · Data updated 2026-11-12
This study is looking at how a specific gut bacterium called Bacteroides vulgatus might affect inflammation and diabetes in people, hoping to find out how different strains of this bacterium can influence our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $648,179 |
| NIH project number | 5R01DK136231-03 |
| Project ID | NIH-11083754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory bowel diseases or adult-onset diabetes.
✕Less likely to help
Patients without gastrointestinal issues or those not affected by diabetes may not benefit from this research.
What this research studies
This research investigates the role of the gut bacterium Bacteroides vulgatus in influencing inflammation and diabetes in humans. By examining the genetic diversity of different B. vulgatus strains, the study aims to uncover how these variations affect the body's inflammatory responses. Using advanced animal models, researchers will analyze how specific genetic traits of these bacteria contribute to health outcomes, particularly in relation to inflammatory bowel diseases and diabetes. The findings could lead to new insights into how gut microbiota impacts overall health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for inflammatory diseases and diabetes by targeting specific gut bacteria.
How similar studies have gone: Previous research has shown promising results in understanding the gut microbiome's role in health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Rawls, John F — Duke University
- Study coordinator: Rawls, John F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.