Understanding how gut bacteria affect immune responses in HIV-1 patients
Decoding mutualistic microbiota-B cell interactions in the HIV-1-infected gut: impact on immunological non-responders
This study is looking at how HIV affects the gut and the immune system in people living with the virus, to help understand why some patients have ongoing immune problems even after starting treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10877894 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between gut microbiota, immune cells, and HIV-1 in the intestines of infected individuals. It aims to understand how HIV-1 disrupts the mucosal immune system, leading to persistent immune issues even after starting treatment. By analyzing gut tissue and immune populations, the study seeks to uncover the mechanisms behind poor immune recovery in some patients. This collaborative effort involves experts in gastroenterology and mucosal immunology to provide a comprehensive understanding of these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are experiencing suboptimal immune recovery despite receiving combination antiretroviral therapy.
Not a fit: Patients who are not infected with HIV-1 or those who have not started antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for HIV-1 patients, enhancing their immune recovery and overall health.
How similar studies have performed: Previous research has shown that gut microbiota significantly influence immune responses, suggesting that this approach could yield valuable insights into HIV-1 treatment.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Mehandru, Saurabh — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mehandru, Saurabh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.