Understanding how gut bacteria affect hormone levels in prostate cancer patients
Deciphering microbial contribution to androgen bioavailability in castration resistant prostate cancer patients
['FUNDING_R21'] · UNIVERSITY OF FLORIDA · NIH-10766201
This study is looking at how the bacteria in your gut might affect hormone levels in men with castration-resistant prostate cancer, and it needs patients to share stool samples and health information to help uncover how these bacteria could influence treatment outcomes.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10766201 on ClinicalTrials.gov |
What this research studies
This research investigates the role of gut microbiome in influencing androgen levels in patients with castration-resistant prostate cancer (CRPC). It explores how specific gut bacteria can convert testosterone precursors into active testosterone, potentially impacting treatment outcomes. By analyzing the interactions between androgens and gut bacteria, the study aims to uncover new insights into hormone bioavailability and its effects on cancer progression. Patients may be involved in providing stool samples and health data to help researchers understand these microbial interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with castration-resistant prostate cancer who are undergoing androgen deprivation therapy.
Not a fit: Patients with prostate cancer who are not castration-resistant or those who are not undergoing any form of androgen deprivation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for prostate cancer by optimizing androgen levels through microbiome modulation.
How similar studies have performed: Previous studies have shown promising results regarding the influence of gut microbiota on hormone metabolism, indicating that this research builds on established findings.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GHARAIBEH, RAAD — UNIVERSITY OF FLORIDA
- Study coordinator: GHARAIBEH, RAAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.