Understanding how gut bacteria affect Candida growth in the digestive system
Official title: Metabolic Regulation of Candida GI Tract Colonization
Funded at Sloan-Kettering Inst Can Research · NIH-11061785 · Data updated 2026-11-12
This study is looking at how the good bacteria in your gut and their byproducts can help stop the growth of Candida yeast, which can cause infections, and it aims to find new ways to help people manage these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $541,200 |
| NIH project number | 5P01AI179406-02 |
| Project ID | NIH-11061785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults undergoing allogeneic hematopoietic cell transplantation or those with gastrointestinal Candida infections.
✕Less likely to help
Patients who do not have Candida infections or are not undergoing treatments that affect their gut microbiota may not benefit from this research.
What this research studies
This research investigates how the gut microbiota and its metabolites influence the colonization of Candida, a type of yeast, in the gastrointestinal tract. The study employs both in vitro and in vivo methods to identify specific short-chain and medium-chain fatty acids that may inhibit Candida growth. By analyzing fecal samples from patients, the research aims to uncover the mechanisms behind Candida colonization resistance and how gut bacteria can help prevent infections. This could lead to new strategies for managing Candida-related conditions in patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Candida infections by harnessing the power of gut bacteria.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in fungal infections, indicating that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hohl, Tobias M — Sloan-Kettering Inst Can Research
- Study coordinator: Hohl, Tobias M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.