Understanding how gut bacteria affect Campylobacter jejuni infections
Official title: Campylobacter jejuni restriction by the intestinal microbiota
Funded at Yale University · NIH-10909342 · Data updated 2026-11-12
This study is looking at how the good bacteria in the gut can help protect chickens from getting sick from a common bug that causes diarrhea, with the hope that it can lead to new ways to keep people safe from serious complications like Guillain-Barré Syndrome.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $209,375 |
| NIH project number | 5R21AI173465-02 |
| Project ID | NIH-10909342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced foodborne illnesses or are at risk for developing complications from Campylobacter jejuni infections.
✕Less likely to help
Patients who have not been exposed to Campylobacter jejuni or do not have a history of foodborne illnesses may not benefit from this research.
What this research studies
This research investigates how the intestinal microbiota influences the colonization of Campylobacter jejuni, a common cause of foodborne diarrhea. By using a germ-free chicken model, the study aims to uncover the mechanisms that allow certain individuals to resist infection despite exposure. The goal is to identify specific bacterial compositions that may protect against the pathogen, which could lead to new prevention strategies for those at risk of severe complications like Guillain-Barré Syndrome.
Why it matters
Potential benefit: If successful, this research could lead to new ways to prevent serious complications from Campylobacter jejuni infections in susceptible individuals.
How similar studies have gone: Previous research has shown that understanding the role of gut microbiota can lead to significant advancements in preventing infections, suggesting a promising avenue for this study.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Galan, Jorge E — Yale University
- Study coordinator: Galan, Jorge E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.