Understanding how gut bacteria affect C. difficile colonization
Identifying sources of variation in microbiome-pathogen dynamics during Clostridioides difficile colonization
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11322257
This work explores how the helpful bacteria in our gut protect us from C. difficile, especially after taking antibiotics.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11322257 on ClinicalTrials.gov |
What this research studies
Many people carry C. difficile without getting sick, but they can still spread it or develop an infection, particularly after antibiotic use. This project uses special animal models that mimic what happens in people to understand why some individuals are protected while others get sick. We want to learn how different types of gut bacteria protect against C. difficile and how antibiotics might make someone more vulnerable. The goal is to find ways to predict who is at risk and develop new treatments.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to benefit individuals at risk for or suffering from Clostridioides difficile infection, especially those who are asymptomatic carriers or have recently taken antibiotics.
Not a fit: Patients without a risk of Clostridioides difficile infection or those not exposed to antibiotics would likely not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent C. difficile infections, better predict who is at risk, and develop new treatments that work with our natural gut bacteria.
How similar studies have performed: While the role of the microbiome in C. difficile infection is well-established, this approach uses novel animal models to specifically address variations seen in asymptomatically-colonized patients, which is a less explored area.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FISHBEIN, SKYE REBECCA — OHIO STATE UNIVERSITY
- Study coordinator: FISHBEIN, SKYE REBECCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.