Understanding how gut bacteria affect antibiotic resistance in children
Bacterial Community Barrier to Vancomycin Resistant Enterococcus
['FUNDING_R21'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11103176
This study is looking at how the bacteria in the intestines of children with weakened immune systems can affect the growth of a harmful germ called vancomycin-resistant Enterococci (VRE), with the goal of finding ways to help prevent infections in these kids.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11103176 on ClinicalTrials.gov |
What this research studies
This research investigates how the gut microbiome influences the colonization of vancomycin-resistant Enterococci (VRE) in immunocompromised children. It aims to identify specific bacteria in the intestines that can either promote or inhibit the growth of VRE. By using advanced molecular techniques and bioinformatics, the study will explore the interactions between these gut microbes and VRE, providing insights into how antibiotic resistance develops. The findings could lead to new strategies for preventing infections in vulnerable pediatric populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised children under the age of 11 who are at risk for infections caused by antibiotic-resistant bacteria.
Not a fit: Patients who are not immunocompromised or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies against antibiotic-resistant infections in children.
How similar studies have performed: Other research has shown success in understanding the role of the microbiome in antibiotic resistance, making this approach promising.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARGOLIS, ELISA B H — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: MARGOLIS, ELISA B H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.