Understanding how gut bacteria affect a key enzyme related to heart and metabolic health
Soluble epoxide hydrolase: assessment of in vivo activity and regulation by gut microbiota
This study is looking at how a specific enzyme affects heart and metabolic health, and it's developing a new way to measure this enzyme in people to help improve treatments for diabetes and heart diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10786115 on NIH RePORTER |
What this research studies
This research investigates the role of soluble epoxide hydrolase (sEH), an enzyme that influences cardiovascular and metabolic health by regulating lipid mediators known as epoxyeicosatrienoic acids (EETs). The study aims to develop a new method called Simultaneous Analysis of Multiple Indices (SAMI) to measure sEH activity in vivo, particularly in humans, where traditional methods are challenging. By analyzing various epoxide-diol pairs in the blood, the research seeks to better understand how sEH is regulated and how it can be targeted to improve health outcomes in conditions like diabetes and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diabetes or cardiovascular diseases who may benefit from improved metabolic health.
Not a fit: Patients without metabolic or cardiovascular conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cardiovascular and metabolic health by targeting sEH activity.
How similar studies have performed: Previous research has shown promising results in targeting sEH for improving cardiovascular health, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Youn, Jang H. — University of Southern California
- Study coordinator: Youn, Jang H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.