Understanding how gut bacteria acquire essential metals
Microbiota Metallophores: Probing Interactions and Nutrient Dynamics of the Human Gut
['FUNDING_OTHER'] · UNIVERSITY OF DENVER (COLORADO SEMINARY) · NIH-11143934
This study is looking at how gut bacteria, like Bacteroides thetaiotaomicron, compete for important nutrients like iron and zinc, especially when the gut is inflamed, to help us understand how these tiny helpers affect our health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF DENVER (COLORADO SEMINARY) (nih funded) |
| Locations | 1 site (DENVER, UNITED STATES) |
| Trial ID | NIH-11143934 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between gut bacteria and their ability to acquire essential metal nutrients like iron and zinc, which are crucial for their growth and function. By studying the production of metallophores—molecules that bind metals with high affinity—the research aims to uncover how these bacteria compete for limited resources in the human gut. The approach includes examining how specific bacteria, such as Bacteroides thetaiotaomicron, utilize these metallophores to thrive in metal-limited environments, particularly during conditions like bowel inflammation. This work could provide insights into the microbiome's role in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal issues or those interested in understanding the role of gut bacteria in their health.
Not a fit: Patients with no gastrointestinal concerns or those not interested in microbiome-related health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing gut health and treating conditions related to microbiome imbalances.
How similar studies have performed: Other research has shown promising results in understanding microbial interactions and nutrient acquisition in various environments, suggesting that this approach could yield valuable insights.
Where this research is happening
DENVER, UNITED STATES
- UNIVERSITY OF DENVER (COLORADO SEMINARY) — DENVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARON, ALLEGRA — UNIVERSITY OF DENVER (COLORADO SEMINARY)
- Study coordinator: ARON, ALLEGRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.