Understanding how GTP metabolism affects melanoma progression
Interrogating the role of GTP metabolism in Rac1-driven phenotypes in melanoma
This study is looking at how a molecule called GTP affects a protein named Rac1, which helps melanoma, a serious skin cancer, grow and spread, with the goal of finding new ways to improve treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10949002 on NIH RePORTER |
What this research studies
This research investigates the role of GTP metabolism in the behavior of melanoma, a highly aggressive skin cancer. It focuses on a specific protein, Rac1, which is known to drive tumor growth and spread. The researchers aim to understand how changes in GTP levels influence Rac1 activity and, consequently, melanoma cell invasion and resistance to treatments. By studying the interactions between GTP metabolism enzymes and Rac1, the research seeks to identify potential new therapeutic targets for improving treatment outcomes in melanoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic melanoma, particularly those with mutations in the Rac1 gene.
Not a fit: Patients with non-melanoma skin cancers or those without the specific Rac1 mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve survival rates for patients with metastatic melanoma.
How similar studies have performed: Previous research has shown promising results in targeting GTP metabolism in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Wolff, David W — Augusta University
- Study coordinator: Wolff, David W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.