Understanding how GSK3A affects gene regulation and cohesin function
Official title: Investigating the Role of GSK3A in Cohesin Dynamics and Gene Regulation
Funded at University of Pennsylvania · NIH-11162218 · Data updated 2026-11-12
This study is looking at a protein called GSK3A to see how it affects another important protein that helps keep our genes organized, which could help find new treatments for conditions like Cornelia de Lange Syndrome.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HD118759-01 |
| Project ID | NIH-11162218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cohesinopathies, particularly those with Cornelia de Lange Syndrome.
✕Less likely to help
Patients without cohesin-related disorders or those not affected by genetic mutations in the cohesin complex may not benefit from this research.
What this research studies
This research investigates the role of GSK3A, a protein that may negatively regulate cohesin, which is crucial for proper gene expression and DNA organization. By examining how GSK3A influences cohesin dynamics, the research aims to uncover potential therapeutic targets for patients with cohesinopathies, such as Cornelia de Lange Syndrome. The approach includes high-throughput imaging and analysis of cellular processes to identify how GSK3A impacts chromatin structure and gene regulation. This could lead to new strategies for treating developmental disorders linked to cohesin dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with cohesinopathies.
How similar studies have gone: Previous research has shown promise in targeting cohesin regulators, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Shapiro, Joanatta — University of Pennsylvania
- Study coordinator: Shapiro, Joanatta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.