Understanding how GSK3A affects gene regulation and cohesin function
Investigating the Role of GSK3A in Cohesin Dynamics and Gene Regulation
This study is looking at a protein called GSK3A to see how it affects another important protein that helps keep our genes organized, which could help find new treatments for conditions like Cornelia de Lange Syndrome.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11162218 on NIH RePORTER |
What this research studies
This research investigates the role of GSK3A, a protein that may negatively regulate cohesin, which is crucial for proper gene expression and DNA organization. By examining how GSK3A influences cohesin dynamics, the research aims to uncover potential therapeutic targets for patients with cohesinopathies, such as Cornelia de Lange Syndrome. The approach includes high-throughput imaging and analysis of cellular processes to identify how GSK3A impacts chromatin structure and gene regulation. This could lead to new strategies for treating developmental disorders linked to cohesin dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cohesinopathies, particularly those with Cornelia de Lange Syndrome.
Not a fit: Patients without cohesin-related disorders or those not affected by genetic mutations in the cohesin complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve outcomes for patients with cohesinopathies.
How similar studies have performed: Previous research has shown promise in targeting cohesin regulators, suggesting potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Shapiro, Joanatta — University of Pennsylvania
- Study coordinator: Shapiro, Joanatta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.