Understanding how Gsα controls hormone signals
Control of allelic Gsα expression for regulating hormone signaling
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11181291
This project looks at how a protein called Gsα helps control hormone signals in the body, especially for conditions like Albright syndrome.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11181291 on ClinicalTrials.gov |
What this research studies
Our bodies rely on a protein called Gsα to help many hormones send their messages. When the gene for Gsα, called GNAS, doesn't work correctly, it can lead to problems with hormone actions and bone development, such as in Albright syndrome. This project explores a unique way Gsα signaling is controlled, where some cells use Gsα mainly from one parent's gene. We aim to understand how this specific control affects hormone signaling and contributes to conditions like pseudohypoparathyroidism type-1A, where patients experience hormone deficiencies and other physical symptoms. By learning more about this process, we hope to uncover new ways to help patients with these disorders.
Who could benefit from this research
Good fit: This research is relevant for patients affected by conditions like Albright syndrome 1 or pseudohypoparathyroidism type-1A, which involve issues with hormone signaling and bone development.
Not a fit: Patients whose conditions are unrelated to Gsα signaling or GNAS gene mutations would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of hormone-related disorders and potentially new ways to manage conditions like Albright syndrome and pseudohypoparathyroidism type-1A.
How similar studies have performed: This foundational research aims to better understand a specific biological mechanism, rather than testing a previously successful treatment approach.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASTEPE, MURAT — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: BASTEPE, MURAT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Albright syndrome 1