Understanding how growth hormone affects metabolic diseases like fatty liver disease
BLRD Research Career Scientist Award Application
['FUNDING_OTHER'] · JESSE BROWN VA MEDICAL CENTER · NIH-10948092
This study is looking at how growth hormone and a related protein affect metabolism in adults, especially in veterans who may be more likely to develop liver problems, to find new ways to help improve their health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JESSE BROWN VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10948092 on ClinicalTrials.gov |
What this research studies
This research investigates the role of growth hormone (GH) and insulin-like growth factor I (IGF1) in regulating metabolic functions in adults. It focuses on how disruptions in GH and IGF1 signaling can lead to metabolic diseases, particularly non-alcoholic fatty liver disease (NAFLD). The research employs clinical and experimental methods to explore the connections between GH signaling, fat accumulation in the liver, and related health issues, especially in populations such as veterans who are at higher risk. By examining genetic factors and metabolic pathways, the study aims to uncover potential therapeutic targets for improving metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults, especially veterans, who are experiencing metabolic diseases such as obesity, type 2 diabetes, or non-alcoholic fatty liver disease.
Not a fit: Patients who do not have metabolic diseases or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic diseases, particularly non-alcoholic fatty liver disease, improving health outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of GH signaling in metabolic diseases, indicating that this approach has potential for success.
Where this research is happening
CHICAGO, UNITED STATES
- JESSE BROWN VA MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KINEMAN, RHONDA D — JESSE BROWN VA MEDICAL CENTER
- Study coordinator: KINEMAN, RHONDA D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.